In honor of Mental Health Awareness Month, let’s explore the powerful connection between mental well-being and the food we eat. Research continues to show that gut health plays a meaningful role in mood, stress regulation, and overall mental health.

The gut and brain are in constant communication through a complex network of nerves, hormones, and gut bacteria known as the gut-brain connection. Understanding how the gut and brain work together helps explain why nutrition, stress, and digestion are so closely linked.

The Gut-Brain Axis: Your "Second Brain"

The gut is often referred to as the “second brain” because it contains its own nervous system and produces many of the same neurotransmitters as the brain. When the gut is out of balance, mental health can be affected as well.

What is the Gut-Brain Axis?

The gut-brain axis is the two-way communication system between the gastrointestinal tract and the central nervous system. This connection involves complex interactions between the nervous system, immune system, endocrine system, and gut microbiota.

The Enteric Nervous System

The enteric nervous system (ENS) is a network of nerves that lines the digestive tract. It's sometimes called the "second brain" because it controls digestion and communicates with the brain. 

The gut-brain connection diagram, two-way communication between brain and gut, stress and anxiety communicates to gut and gut causes shifts in mood
  • The ENS sends signals to the brain to indicate when you're hungry or full. 

  • The brain also sends signals to the ENS, which can trigger emotional responses.

  • The vagus nerve, a major component of the gut-brain axis, plays a crucial role in transmitting signals between the gut and the brain, influencing everything from mood to digestion.

Through this axis, the gut microbiome produces neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), which can directly affect emotional well-being, cognitive function, and stress resilience. Additionally, the gut microbiota modulates inflammation, a key factor in mental health conditions such as depression and anxiety.

The Science of the Gut-Brain Connection

Research shows that gut-focused therapies such as probiotics, fiber-rich diets, cognitive behavioral therapy, and gut-directed hypnotherapy can significantly improve mental health outcomes. For example, people with IBS often experience up to a 75% reduction in symptoms when using gut-directed hypnotherapy or CBT, highlighting just how interconnected the brain and gut truly are.

How Nutrition Supports Gut and Brain Health

Proteins: Building Blocks for a Happy Brain

Proteins, made up of amino acids, are essential for both gut and brain health. These amino acids help produce neurotransmitters, which are the chemical messengers that keep our gut and brain in sync.

For example, Tryptophan helps create serotonin, which plays a big role in mood, sleep, and even gut function. Fun fact: around 95% of serotonin is actually made in the gut! Tyrosine helps produce dopamine and norepinephrine—key players in motivation, focus, and energy.

On top of neurotransmitters, proteins:

  • Help maintain a healthy gut lining, which keeps harmful stuff out of the bloodstream.

  • Feed the beneficial bacteria in our gut that support mental clarity and emotional balance.

  • Influence how our body responds to stress by supporting neurotransmitter balance and gut function.

Fats: Essential for Gut-Brain Harmony

Two fresh salmon fillets on a piece of parchment paper placed on a wooden cutting board

About 60% of the brain is fat, and healthy fats are crucial for gut health too. Fats influence gut bacteria and produce short-chain fatty acids (SCFAs), which help keep inflammation in check and boost brain function.

Why fats matter:

  • Myelin formation, the protective coating around nerves, helps gut-brain communication run smoothly.

  • Omega-3 fatty acids, found in foods like salmon and walnuts, have anti-inflammatory properties that support both gut and mental health.

  • Diets too low in fat have been linked to higher rates of mood disorders like depression

Carbohydrates: Your Brain’s Favorite Fuel

Gut-brain connection, Curly pipe cleaners resembling  a person with long hair

Carbs break down into glucose, which your brain and gut rely on to function properly. The gut bacteria also ferment certain carbs, producing compounds that support neurotransmitter production.

Carbs also:

  • Keep blood sugar levels steady, which helps with mood and focus.

  • Boost serotonin production, helping you feel happier and more balanced (Astonishingly, about 95% of serotonin is produced in the gut).

  • Prevent energy crashes that can leave you feeling sluggish and irritable.

The Role of the Gut Microbiome in Mental Health

The gut microbiome consists of trillions of microorganisms, including bacteria, viruses, fungi, and other microbes that play a critical role in digestion, immunity, and mental health. A diverse and balanced microbiome helps regulate neurotransmitter production, reduce inflammation, and maintain the gut barrier function.

Key Functions of the Gut Microbiome

  • Producing neurotransmitters: Gut bacteria synthesize neurotransmitters like serotonin and dopamine, which influence mood and cognitive function.

  • Regulating inflammation: A healthy microbiome helps control systemic inflammation, which has been linked to mental health disorders.

  • Supporting the immune system: The gut microbiota communicates with immune cells to maintain a balanced immune response, reducing the risk of chronic inflammation and autoimmune conditions.

  • Aiding nutrient absorption: The microbiome helps break down food components, facilitating the absorption of essential vitamins and minerals that support brain health.

What Happens When the Microbiome Is Out of Balance?

An imbalance in gut bacteria, known as dysbiosis, can lead to increased intestinal permeability (leaky gut), triggering systemic inflammation and impacting mental health. Factors such as diet, stress, antibiotics, and lifestyle choices can all influence the balance of the gut microbiome.

Frequently Asked Questions About the Gut-Brain Connection

  • Yes. Research shows gut inflammation and microbiome imbalance can influence mood through neurotransmitter production and inflammation pathways.

  • Stress directly impacts gut motility, digestion, and microbiome balance through the gut-brain axis.

  • Nutrition is one important piece of mental health care, but it works best alongside therapy, medical support, and lifestyle factors.

Takeaways: Nourish Your Gut, Support Your Mind

The connection between your gut and brain is powerful. Supporting gut health through consistent nourishment, balanced meals, and stress care can positively impact mental well-being. Nourishment is not just about fueling the body. It is an essential part of caring for the mind. If you would like personalized support for gut health, mental health, or both, our Registered Dietitian Nutritionists at CV Wellbeing are here to help. Contact us to schedule an appointment and explore care tailored to your unique needs.

Alison Swiggard, MS, RDN, LD, registered dietitian nutritionist at CV Wellbeing
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